What common medication is used as an antidote for opioid overdose?

Naloxone is a common medication used as an antidote for opioid overdose. It is an opioid antagonist, which means it works by binding to the same receptors in the brain that opioids do, thereby reversing the effects of the opioids and restoring normal respiratory function. This capability makes naloxone critical in emergency situations where someone has experienced an overdose, as it can quickly counteract the life-threatening effects of opioid toxicity.

Naloxone acts very quickly, often within minutes, providing a crucial window to stabilize the individual until further medical treatment can be provided. Its use is supported by widespread training initiatives and availability, including in public settings, to improve response to opioid overdoses.

Other medications listed serve different purposes. For instance, methadone and buprenorphine are primarily used for pain management and in addiction treatment, respectively, and while they can influence opioid receptors, they do not effectively reverse opioid overdose. Acamprosate is used for alcohol dependence and is not related to the treatment of opioid overdose.