What is considered the first-line treatment for major depressive disorder?

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Psychotherapy is recognized as a first-line treatment for major depressive disorder, particularly when it involves evidence-based modalities such as cognitive-behavioral therapy (CBT) or interpersonal therapy (IPT). These therapies are effective in helping individuals identify and change negative thought patterns and behaviors that contribute to depression. They aim to provide patients with coping strategies and skills that enhance emotional regulation and address interpersonal issues that may exacerbate depressive symptoms.

The effectiveness of psychotherapy can vary based on the individual's specific situation, including the duration and severity of depression, as well as personal preferences. In many cases, psychotherapy is preferred, especially for mild to moderate cases of depression, and can be used either alone or in conjunction with medications for more severe cases.

Other treatments like medication therapy may also be necessary, particularly in cases where depression is more severe or treatment-resistant. However, psychotherapy remains a foundational approach due to its focus on the psychological and social factors contributing to the disorder, which medication alone may not address adequately.

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