What is the BLACK BOX WARNING associated with naltrexone for alcohol use disorder?

Naltrexone carries a black box warning regarding the risk of severe liver disease. This warning highlights the potential hepatotoxicity associated with the medication, which is particularly important for patients who may have existing liver dysfunction or who consume alcohol heavily. In clinical practice, monitoring liver function is vital when prescribing naltrexone due to its effects on liver enzymes. The warning is especially pertinent because elevated liver enzymes or pre-existing liver conditions can worsen with the introduction of naltrexone. This aspect of the drug’s safety profile is crucial for clinicians to consider when evaluating a patient’s suitability for this treatment, especially for those with a history of liver disease or heavy alcohol use. Other options do not reflect the specific risks associated with naltrexone in the context of alcohol use disorder.