Which antipsychotic is indicated for reducing anxiety and aiding in weight gain for patients with anorexia nervosa?

Olanzapine is often indicated for use in patients with anorexia nervosa because of its ability to help reduce anxiety and promote weight gain. This atypical antipsychotic has been found to have a sedative effect, which can help alleviate anxiety symptoms that often accompany eating disorders. Additionally, olanzapine has a side effect profile that includes potential weight gain, which can be beneficial for patients suffering from anorexia nervosa who struggle with malnutrition and need to increase their body weight in a controlled and supervised manner.

The mechanism by which olanzapine assists in weight gain includes its action on serotonin and dopamine receptors, which can enhance appetite. Clinically, its use has been shown to improve weight gain outcomes in patients with anorexia nervosa compared to some other medications.

While other antipsychotics may also have some impact on anxiety or weight, olanzapine is specifically recognized for its effectiveness in this population when weight restoration is a primary goal alongside managing anxiety.