Which of the following medications is most likely to cause agranulocytosis?

The medication most likely to cause agranulocytosis is Clozapine. Agranulocytosis is a potentially life-threatening condition characterized by a dangerously low level of neutrophils, a type of white blood cell that plays a crucial role in fighting infections.

Clozapine is unique among antipsychotics due to its mechanism of action and the specific risk profile associated with it. It is often used for treatment-resistant schizophrenia and has been found to be more effective than other antipsychotics for certain patients. However, it has a significant side effect profile, with agranulocytosis being the most critical concern.

The risk of agranulocytosis with clozapine is substantial enough that patients on this medication typically undergo regular monitoring of their white blood cell counts to detect any early signs of neutropenia. This proactive approach helps to manage and mitigate the risk associated with this drug.

In contrast, while the other options listed may have various side effects, they do not carry the same risk for agranulocytosis as clozapine does. Risperidone, Olanzapine, and Quetiapine can have their own side effect profiles, including metabolic syndrome and sedation, but they do not